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Ellman International Inc ic50 values
Ic50 Values, supplied by Ellman International Inc, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ic50+values/ic50+values/pm41242410-87-19-14
Average 86 stars, based on 1 article reviews

ic50 values - by Bioz Stars, 2026-10

86/100 stars

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Article Title: Design, Synthesis, and Evaluation of Acetylcholinesterase and Butyrylcholinesterase Dual-Target Inhibitors against Alzheimer’s Diseases
Article Snippet: According to the method described by Ellman [32], the data were expressed by IC50 values.

Diffusion-based Assay:

Article Title: The position of fluorine in CP-118,954 affects AChE inhibition potency and PET imaging quantification for AChE expression in the rat brain.
Article Snippet: The in vitro inhibition potency against acetylcholinesterase (AChE) of fluorinated derivatives of CP-118,954 (1) has been shown to depend upon the position of aromatic fluorine (F) substitution on the N-benzyl moiety.. Indeed, the meta-F-substituted compound 3 (IC50 = 1.4 nM) shows similar potency with the parent compound 1 (IC50 = 1.2 nM), whereas the ortho-F derivative 2 (IC50 = 3.2 nM) and para-F derivative 4 (IC50 = 10.8 nM) were found to be less potent AChE inhibitors.. A comparative in vivo microdialysis study in rats showed that 3 has the strongest effect on the neuropharmacological properties as AChE inhibitor.

Modification:

Article Title: Dual cholinergic modulation in dementia: Quinuclidine carbamates targeting butyrylcholinesterase and α7 nicotinic receptor.
Article Snippet: Inhibitory potency of the prepared quinuclidine carbamates on hBChE was determined using the modified Ellman’s assay, and the respective IC50 values are presented in Table 1. .. Inhibitory potency of the prepared quinuclidine carbamates on hBChE was determined using the modified Ellman’s assay, and the respective IC50 values are presented in Table 1. ..